The Port Dock entered South Australian hotel history on June 19, 1855, when its licence was proclaimed, along with 15 other new hotels in the rapidly developing colony. Port Adelaide already was a thriving port and refreshments were in great demand. In 1883 the original hotel was rebuilt.

The Port Dock Brewery Hotel is a working brewery with historic cellars and tap room and has beer tastings together with quality food at modest prices. There are maritime artefacts including items from the Titanic and models of ships.

2004 and 2006 South Australian Tourism Award Winner. 2007 and 2008 South Australian Tourism Awards Silver Medallist.